Coding

Part:BBa_K4156086:Design

Designed by: Zheng Huang   Group: iGEM22_LZU-CHINA   (2022-10-06)


CCL21


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

It is important to note that CCL21 is a new part that we uploaded this year. And as a toxic protein, it does not exist in the igem whitelist. We have drafted a safety precaution about CCL21 and submitted a check-in form to igem official. The details can be seen on our wiki.


Source

CCL21 is mainly produced by lymphatic endothelial cells, and its interaction with surface CCR7 such as dendritic cells and T cells is the main determinant of lymphatic migration and lymph node homing of immune cells.


References